Ingredient profile
L-Citrulline in Memodyne: Small Doses of a Workout Amino Acid
Memodyne lists L-citrulline HCl 100 mg and L-citrulline malate 100 mg, so 200 mg per capsule. Inside the body, citrulline becomes arginine. NIH reviewers found weak support for it even in exercise, where trials used 3 to 8 grams. No source we cite links it to memory or brain fog, and the label does not explain the two forms.
Written by the Memodyne editorial teamUpdated
On the label
What amount of L-citrulline does Memodyne list?
Two lines of 100 mg, which together come to 200 mg of citrulline ingredients.
Lines 5 and 6 on the panel read L-Citrulline HCl 100 mg and L-Citrulline Malate 100 mg. Both forms carry a partner molecule, so the actual citrulline in a capsule falls a little short of 200 mg. The label does not print the split.
| Label name | L-Citrulline HCl |
|---|---|
| Scientific name | Amino acid |
| What it is | Amino acid |
| Position in the list | 5 of 7 (every line prints its own amount) |
| Per capsule | 100 mg |
| Amount used in research | Exercise research used 3-8 g; ODS finds weak support |
| Strength of evidence | No memory evidence |
| Traditional or marketed use | Converted to arginine in the body |
| Main caution | Stomach upset in some studies; safety over months is not well tested. |
Two forms
HCl or malate: how do Memodyne's two citrulline forms differ?
Same amino acid, different partner. The bottle says nothing about why it uses both.
L-citrulline HCl
Citrulline as a hydrochloride salt. Salt forms like this are common in supplement powders.
L-citrulline malate
Citrulline joined to malic acid, a natural acid found in fruit. This is the form in the best-known weightlifting trial, at 8 g (NIH ODS, Exercise supplements).
We found no head-to-head research in our sources that ranks one form above the other for any purpose. Treat the pair as 200 mg of citrulline ingredients and judge that total.
How it works
How does the body use L-citrulline?
It turns citrulline into arginine, which is why sellers pair the two.
Your body produces citrulline itself, and small amounts come from foods such as watermelon. It is not used to build proteins. Instead, the body converts it into L-arginine, the raw material for nitric oxide.
That conversion is the usual selling point for citrulline in sports powders: more citrulline in, more arginine to work with. Our sources do not test that idea for Memodyne, and the label makes no claim about it.
- Citrulline goes in, arginine comes out.
- Arginine feeds nitric oxide, which helps vessels relax.
- Even at gram doses, arginine rarely raised nitric oxide in athletes (NIH ODS, Exercise supplements). More on the L-arginine profile.
Research
What did NIH reviewers find in citrulline exercise studies?
Mixed results at gram doses, and an overall verdict of weak support.
| Study | Dose | Result |
|---|---|---|
| 41 weightlifters | 8 g citrulline malate | Extra reps and milder muscle soreness; 6 of 41 had stomach discomfort |
| Treadmill test | 3 g before testing, or 9 g spread over 24 hours | Did worse than placebo |
| Nonathletes | Up to 6 g a day for 4 weeks | No adverse effects seen |
| Long-term use | Months | Safety not adequately assessed |
| Memory | Any | Not covered |
Overall, the NIH judges this body of work too thin to back citrulline firmly, even for the exercise goals it was tested on. Memory was never the question in these trials.
Dose gap
Can 200 mg of citrulline do anything measurable?
Unlikely. A capsule supplies roughly one-fifteenth of the smallest trial dose.
Fifteen capsules would break the label's one-a-day rule. The math shows why a measurable effect is unlikely, not a reason to take more.
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Does L-citrulline help brain fog or blood flow to the brain?
No good human evidence says so, and the dose here is far smaller than any trial.
Searches for citrulline and the brain mostly turn up patents, animal work and lab studies. A patent shows that someone filed an idea; it is not proof the idea works. The NIH fact sheet, our main citrulline source, does not mention memory or focus at all (NIH ODS, Exercise supplements).
Medicines, low vitamin B12, depression and alcohol can all affect memory (MedlinePlus, Memory loss). A checkup can sort those out. A 200 mg amino acid dose cannot. Our memory health guide lists the signs that need a visit.
Safety
Is L-citrulline safe, and when is a medicine check needed?
Short-term use looked well tolerated. Anyone on pressure or ED medicines should get a check.
In the trials, stomach discomfort was the main complaint, and it came at 8 g, forty times the amount here (NIH ODS, Exercise supplements). Up to 6 g a day for four weeks caused no problems in nonathletes. What nobody knows well is how it behaves over many months.
Citrulline becomes arginine, and Mayo Clinic flags arginine taken alongside pressure pills, nitrates or sildenafil as a route to blood pressure that is too low (Mayo Clinic, L-arginine). Memodyne also contains arginine directly. Ask your doctor or pharmacist before you start, and keep taking your prescribed medicine.
Cautions for the other lines: Memodyne side effects.
Bottom line
What should you make of the citrulline in Memodyne?
An honest label line with a dose too small to compare with any trial.
In its favor
- Both forms print exact amounts
- Well under the dose tied to stomach upset
- Short-term safety looked fine in studies
Against it
- Weak support even for exercise
- No memory research in our sources
- Adds to arginine's medicine concerns
See every line side by side on the ingredient overview.
FAQ
L-citrulline in Memodyne: questions
Can Memodyne's citrulline clear brain fog?
Nothing solid suggests it. Our main source on citrulline covers exercise only, and the brain results that come up online are patents, animal studies and lab work. Brain fog that lingers deserves a checkup, since several causes are treatable.
Is citrulline malate better than L-citrulline HCl?
Our sources do not compare the two directly. The 8 g weightlifting trial used malate (NIH ODS, Exercise supplements), but that says nothing about 100 mg. In Memodyne each form is 100 mg, and the label does not explain the pairing.
Why does Memodyne contain both citrulline and arginine?
The label gives no reason. In general, the body turns citrulline into arginine, so sellers often pair them to target nitric oxide. Exercise research found little nitric oxide change from arginine itself (NIH ODS, Exercise supplements), so the pairing is a theory, not a tested result.
Does 200 mg of citrulline cause side effects?
None are expected at 200 mg from what the studies show. Stomach discomfort turned up in some people taking 8 g (NIH ODS, Exercise supplements). How it acts over many months is still unclear, and the arginine in the same capsule has its own cautions.
Is L-citrulline safe with erectile dysfunction pills?
Check with your prescriber before combining them. Your body changes citrulline to arginine, and Mayo Clinic lists sildenafil among drugs that, with arginine, may push pressure too low (Mayo Clinic, L-arginine). Memodyne contains both, so bring the bottle to your appointment.
How much citrulline did the exercise studies use?
Between 3 and 8 grams, with one group taking 9 grams over a day (NIH ODS, Exercise supplements). Memodyne has 200 mg of citrulline ingredients per capsule, roughly a fifteenth of the lowest of those amounts, and the label allows only one capsule a day.
Who wrote this
Written and reviewed by
Plain-language pages built from the label, the sales page and linked public health sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by a USA authorized retailer that sells Memodyne, not by the maker (the label says distributed by Gex Corporation LLP, Ogden, UT). We earn money when you buy through our order links.
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